programas cribado cancer

Nota bibliográfica cribado c mama 2014-07/08

Irvin VL, Kaplan RM. Screening mammography & breast cancer mortality: meta-analysis of quasi-experimental studies. PLoS One. 2014;9(6):e98105. Available from:  doi: 10.1371/journal.pone.0098105. PMID: 24887150.

CONCLUSIONS: Mammography screening may have modest effects on cancer mortality between the ages of 50 and 69 and non-significant effects for women older than age 70. Results are consistent with meta-analyses of RCTs. Effects on total mortality could not be assessed because of the limited number of studies.

Cedolini C, Bertozzi S, Londero AP, Bernardi S, Seriau L, Concina S, et al. Type of Breast Cancer Diagnosis, Screening, and Survival. Clin Breast Cancer. 2014;14(4):235–40. Available from: doi:

Conclusion The diagnosis of invasive breast cancer with screening in our population resulted in a survival gain at 5 years from the diagnosis, but a longer follow-up is necessary to confirm this data.

Fuhrman BJ, Byrne C. Comparing Mammographic Measures Across Populations (editorial]. J Natl Cancer Inst. 2014;106(5). Available from:  doi: 10.1093/jnci/dju109.

Pettersson A, Graff RE, Ursin G, dos Santos Silva I, McCormack V, Baglietto L, et al. Mammographic Density Phenotypes and Risk of Breast Cancer: A Meta-analysis. J Natl Cancer Inst. 2014;106(5). Available from:  doi: 10.1093/jnci/dju078.

Conclusions The results suggest that percentage dense area is a stronger breast cancer risk factor than absolute dense area. Absolute nondense area was inversely associated with breast cancer risk, but it is unclear whether the association is independent of absolute dense area.

Luqmani Y. Breast screening: an obsessive compulsive disorder. Cancer Causes Control. 2014;1–4. Available from: doi: 10.1007/s10552-014-0430-2.

Brand JS, Czene K, Shepherd JA, Leifland K, Heddson B, Sundbom A, et al. Automated measurement of volumetric mammographic density: a tool for widespread breast cancer risk assessment. Cancer Epidemiol Biomarkers Prev. 2014; Available from: doi: 10.1158/1055-9965.EPI-13-1219.

Conclusions: In a high-throughput setting Volpara performs well and in accordance with the behavior of established density measures. Impact: Automated measurement of volumetric mammographic density is a promising tool for widespread breast cancer risk assessment.

Berg WA. How Well Does Supplemental Screening Magnetic Resonance Imaging Work in High-Risk Women ? J Clin Oncol. 2014;1–5. doi: 10.1200/JCO.2014.56.2975.

Chiarelli AM, Prummel M V, Muradali D, Majpruz V, Horgan M, Carroll JC, et al. Effectiveness of Screening With Annual Magnetic Resonance Imaging and Mammography: Results of the Initial Screen From the Ontario High Risk Breast Screening Program. J Clin Oncol. 2014; Available from: doi: 10.1200/JCO.2013.52.8331.

Conclusion Screening with annual MRI combined with mammography has the potential to be effectively implemented into an organized breast screening program for women at high risk for breast cancer. This could be considered an important management option for known BRCA gene mutation carriers.

Molinié F, Vanier A, Woronoff AS, Guizard A V, Delafosse P, Velten M, et al. Trends in breast cancer incidence and mortality in France 1990–2008. Breast Cancer Res Treat. 2014;147(1):167–75. Available from: doi: 10.1007/s10549-014-3073-9.

 The objective of this work was to detail the incidence and mortality trends of invasive and in situ breast cancer (BC) in France, especially regarding the development of screening, over the 1990–2008 period. Data issued from nine population-based cancer registries were studied. The incidence of invasive BC increased annually by 0.8 % from 1990 to 1996 and more markedly by 3.2 % from 1996 to 2003, and then sharply decreased until 2006 (−2.3 % per year), especially among women aged 50–69 years (−4.9 % per year). This trend was similar whatever the introduction date of the organized screening (OS) program in the different areas. The incidence of ductal carcinoma in situ steadily increased between 1990 and 2005, particularly among women aged 50–69 years and 70 and older. At the same time, the mortality from BC decreased annually by 1.1 % over the entire study period. This decrease was more pronounced in women aged 40–49 and 50–69 and, during the 1990–1999 period, in the areas where OS began in 1989–1991. The similarity in the incidence trends for all periods of implementation of OS in the different areas was striking. This suggests that OS alone does not explain the changes observed in incidence rate. Our study highlights the importance of closely monitoring the changes in incidence and mortality indicators, and of better understanding the factors causing variation.

Houssami N, Macaskill P, Bernardi D, Caumo F, Pellegrini M, Brunelli S, et al. Breast screening using 2D-mammography or integrating digital breast tomosynthesis (3D-mammography) for single-reading or double-reading – Evidence to guide future screening strategies. Eur J Cancer. 2014;50(10):1799–807. Available from: doi: 10.1016/j.ejca.2014.03.017. PMID: 24746887.

CONCLUSION: The evidence we report warrants rethinking of breast screening strategies and should be used to inform future evaluations of 2D/3D-mammography that assess whether or not the estimated incremental detection translates into improved screening outcomes such as a reduction in interval cancer rates.

Renart-Vicens G, Puig-Vives M, Albanell J, Castaner F, Ferrer J, Carreras M, et al. Evaluation of the interval cancer rate and its determinants on the Girona health region’s early breast cancer detection program. BMC Cancer. 2014;14(1):558. Available from:

CONCLUSIONS:The IC rate for the PEDBC is within the expected parameters, with a high proportion of cases of true interval cancers (54.5%) and a low proportion of false negatives (13.6%). The results show that the proportional incidence of IC is within the limits set by European Guidelines. Furthermore, it has been confirmed that IC display more aggressive clinicopathological characteristics than screening breast cancers.

Miller AB. Digital Mammography [editorial].  J Natl Cancer Inst. 2014;106(6). Available from:  doi: 10.1093/jnci/dju125.

Kerlikowske K, Hubbard R, Tosteson ANA. Higher Mammography Screening Costs Without Appreciable Clinical Benefit: The Case of Digital Mammography. J Natl Cancer Inst. 2014;106(8). Available from:  doi: 10.1093/jnci/dju191.

Missinne S, Bracke P. Age differences in mammography screening reconsidered: life course trajectories in 13 European countries. Eur J Public Health. 2014; Available from: doi: 10.1093/eurpub/cku077.

Conclusion: Age differences in mammography screening generally reflect the period effects of national screening policies. This leaves little room for economic theories about human health capital that leave out the institutional context of preventive health care provision.

Lerda D, Deandrea S, Freeman C, López-alcalde J, Neamtiu L, Nicholl C, et al. Report of a European survey breast cancer care services [Internet]. Luxembourg; 2014 p. VI–142. Available from:  doi: 10.2788/51070.

AL Mousa DS, Brennan PC, Ryan EA, Lee WB, Tan J, Mello-Thoms C. How Mammographic Breast Density Affects Radiologists’ Visual Search Patterns. Acad Radiol. (0). Available from: doi:

Conclusions. Increased mammographic breast density changes radiologists' visual search patterns. Dense areas of the parenchyma attracted greater visual attention in both high- and low-mammographic density cases, resulting in faster detection of lesions overlying the fibroglandular dense tissue, along with longer dwell times and greater number of fixations, as compared to lesions located outside the dense fibroglandular regions.

Sarkeala T, Luostarinen T, Dyba T, Anttila A. Breast carcinoma detection modes and death in a female population in relation to population-based mammography screening. Springerplus. 2014;3(1):348. Available from: doi: 10.1186/2193-1801-3-348.

Conclusions The study demonstrates a novel approach to examine associations between breast carcinoma incidence and mortality within and outside population-based screening. The results show mammography screening having a distinct role in overall breast carcinoma incidence and mortality.

Nederend J, Duijm LEM, Louwman MWJ, Roumen RMH, Jansen FH, Voogd AC. Trends in surgery for screen-detected and interval breast cancers in a national screening programme. Br J Surg. 2014;101(8):949–58. Available from:  doi: 10.1002/bjs.9530. PMID: 24828281.

CONCLUSION: Mastectomy rates doubled during a 14-year period of screening mammography and the proportion of positive resection margins decreased, with variation among hospitals. The latter observation stresses the importance of quality control programmes for hospitals treating women with breast cancer.

Hofvind S, Skaane P, Elmore JG, Sebuødegård S, Hoff SR, Lee CI. Mammographic performance in a population-based screening program: before, during, and after the transition from screen-film to full-field digital mammography. Radiology. 2014;272(1):52–62. Available from:  doi: 10.1148/radiol.14131502. PMID: 24689858.

CONCLUSION: After the initial transitional phase from SFM to FFDM, population-based screening with FFDM is associated with less harm because of lower recall and biopsy rates and higher positive predictive values after biopsy than screening with SFM.
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